Making genetic changes in cells used to be very complicated. We used to be able to use viruses and deliver some genes to the cells. We used to be able to make mutations by exposing cells to for instance X-Rays. But, if you were to ask me 10 years ago can you change this one particular gene in a cell, I would say I could do it but it is pretty hard to do. What’s happened in the last five years, its only 5 years old this technology, this technology has allowed us in an astonishing way to go into a normal cell or a cancer cell or even potentially an embryonic stem cell and essentially directionally or intentionally make a mutation in a single gene in an intentional manner. So, I have likened this technology to saying, if you image the human genome as a vast encyclopedia, it would contain 66 full sets of Encyclopedia Britannica but repeating over and over again ACTG, so forth, totally inscrutable to you and me but of course extremely scrutable to a cell. What this technology allows us to do is essentially go into those 66 entire sets of the Encyclopedia Britannica and identify one word in that.